chemical

Angiotensin II acetate

SPA-165

SPA-165_10 mg

Angiotensin II acetate

Non Antibodies

Proteins

Aequorin functional assay / Calcium imaging assay

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Synthetic peptide

AGTR1, AGTR2

Angiotensin II (Ang II) is a natural ligand and a potent angiotensin type 1 and 2 (AT2R and AT1R) receptor agonist. It is important for maintaining normal regulation of cardiovascular function. Ang II is a primary effector peptide of the renin-angiotensin system (RAS) in a variety of tissues and is a major target for blood pressure lowering drugs. Ang II is also responsible for the release of catecholamines from the adrenal medulla and from dopaminergic neurons in the central nervous system1.Angiotensin I is metabolized to the vasoconstricting octapeptide angiotensin II by a circulating converting enzyme (ACE) by removal of two C-terminal residues.Several studies have suggested that increased levels of Ang II in the blood flow may cause endothelial cell dysfunction during the pathogenesis of conditions such as atherosclerosis and hypertension2.

Alomone Labs

Angiotensin II receptors

A Potent Agonist of Angiotensin II Receptors

A Potent Agonist of Angiotensin II Receptors

1046 Da

C50H71N13O12

1 - 300 nM

An Angiotensin II Type 1 and Type 2 Receptor Agonist1.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

68521-88-0

Lyophilized

Contact Alomone Labs for technical support and product customization

DRVYIHPF-OH

No

12352202

yes

no