chemical

[D-Ala7]-Angiotensin I/II (1-7)

SPA-160

SPA-160_1 mg

[D-Ala7]-Angiotensin I/II (1-7)

Non Antibodies

Proteins

Aequorin functional assay / Calcium imaging assay

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Synthetic peptide

AGTR1, MAS1

D-Ala7-Angiotensin I/II (1-7) [D-Ala7-Ang-(1-7)] is a potent and selective synthetic Angiotensin (1-7) Mas receptor antagonist. It has the ability to antagonize several actions of Ang-(1-7), including the antidiuretic effect of the peptide. In addition, it antagonizes the effects of the changes in mean arterial pressure produced by Ang-(1-7) microinjection into the dorsomedial and ventrolateral medulla1-3.Ang-(1-7) is an alternative peptide, a product of the renin-angiotensin system (RAS), with special importance in modulating cell-to-cell communication in cardiovascular and neuronal tissue and plays a role in lowering blood pressure and can decrease the sympathetic nervous system activity.Ang-(1-7) is formed from Ang I by endopeptidases (neprilysin and prolyl oligopeptidase) or by Ang II by carboxypeptidases such as angiotensin-converting enzyme1,2.

Alomone Labs

AT1, Angiotensin-(1-7) Mas receptors

A Potent Agonist of AT1R and Antagonist of Angiotensin-(1-7) Mas Receptor

A Potent Agonist of AT1R and Antagonist of Angiotensin-(1-7) Mas Receptor

873 Da

A-779

Ala-7 = D-Ala.

C39H60N12O11

1 - 200 µM

An Angiotensin (1-7) Antagonist1.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

159432-28-7

Lyophilized

Contact Alomone Labs for technical support and product customization

DRVYIHa-OH

No

12352202

yes

no