chemical

Angiotensin A (1-8)

SPA-105

SPA-105_10 mg

Angiotensin A (1-8)

Non Antibodies

Proteins

Aequorin functional assay / Calcium imaging assay

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Synthetic peptide

AGTR1, AGTR2

Angiotensin A (1-8) is an angiotensin II derivative, a vasoconstrictor peptide of the renin-angiotensin system (RAS) that acts as an angiotensin receptor type 1 and 2 (AT1R and AT2R) agonist.This peptide was first discovered in the human plasma and the sole difference between Ang A and Ang II is Ala1 residue instead of Asp1. Ang A is synthesized by enzymatic decarboxylation of Asp1 of the Ang II sequence1.Angiotensin I is metabolized to the vasoconstricting octapeptide angiotensin II by a circulating converting enzyme (ACE) by removal of two C-terminal residues. It's a natural hormone which the body produces in order to maintain normal regulation of cardiovascular function.Ang II is a primary effector peptide of the RAS in a variety of tissues and is a major target for blood pressure lowering drugs2.Studies show that Ang A has the ability to elicit pressor and renal vasoconstrictor responses in normotensive and hypertensive rats. In isolated perfused rat kidney, the peptide causes a vasoconstrictive effect dependent on AT1 receptors1.

Alomone Labs

Angiotensin receptors

A Potent Agonist of Angiotensin II Receptors

A Potent Agonist of Angiotensin II Receptors

1002 Da

C49H71N13O10

0.5 - 1 nM

An Angiotensin II Type 1 and Type 2 Receptor Agonist1.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

51833-76-2

Lyophilized

Contact Alomone Labs for technical support and product customization

ARVYIHPF-OH

No

12352202

yes

no