SR 48692 | Alomone Labs S-265 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

SR 48692

catalog :

S-265

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat brain membrane (1:200) rat testis and mouse testis lysates (1:400): - 1-3.Anti-Oxytocin ReceptorAntibody (#AVR-013).4-6. Anti-Oxytocin Receptor Antibody preincubated with the negative control antigen.

image 2 :

product information

CAT :

S-265

SKU :

S-265_10 mg

Product Name :

SR 48692

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

SR 48692 is a potent and selective antagonist of neurotensin receptor 1 (NTR1/NTS1). The compound demonstrates hydrophobic and aromatic features1,2. SR 48692 has been shown to antagonize neurotensin receptor actions in intestinal preparations, thus considered to be a useful tool in studying the physiological role of neurotensin receptor in the digestive tract. in vitro studies show that SR 48692 antagonizes NT-induced dopamine release in guinea pig striatal slices and NT-stimulated Ca2+ mobilization in HT29 cells1. In guinea pig ileum preparations, the compound displays an IC50 value of 33.5 nM1.The two neurotensin receptors, NTR1 and NTR2, belong to the family of G-protein-coupled receptors1,2. The receptors are expressed in the brain and gastrointestinal tract where they play a role in pain transmission and intestinal motility.

Supplier :

Alomone Labs

Target :

Neurotensin Receptor 1

Long Description :

SR 48692 (#S-265) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent and Selective Antagonist of Neurotensin Receptor 1

MW :

587.07

Synonyms :

SR48692, Meclinertant, Reminertant

Source :

Synthetic

Molecular formula :

C32H31ClN4O5.

Effective Concentration :

1 nM - 1 µM.

Activity :

SR 48692 is a potent and selective non-peptide antagonist of NTS1 receptors, shown to inhibit neurotensin-stimulated IP production (Ki = 2.45 nM) and NTR1-mediated calcium mobilization1-3.

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

146362-70-1

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid.

more info or order :

Alomone Labs product webpage