SR 48527 | Alomone Labs S-225 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

SR 48527

catalog :

S-225

more info or order :

Alomone Labs product webpage

image

image 1 :

Peptide CSARYLKGSRPGE corresponding to amino acid residues 346-358 of rat Oxtr (AccessionP70536). Intracellular C-terminus.

product information

CAT :

S-225

SKU :

S-225_10 mg

Product Name :

SR 48527

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

SR 48527 is a potent and selective antagonist of neurotensin receptor 1 (NTR1/NTS1). It is an analog of SR 48692 and inhibits neurotensin-stimulated IP production with a Ki value of 24 nM1,2.The two neurotensin receptors, NTR1 and NTR2, belong to the family of G-protein-coupled receptors1,2. The receptors are expressed in the brain and gastrointestinal tract where they play a role in pain transmission and intestinal motility.

Supplier :

Alomone Labs

Target :

Neurotensin Receptor 1

Long Description :

SR 48527 (#S-225) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent and Selective Antagonist of Neurotensin Receptor 1

MW :

549

Synonyms :

SR48527

Source :

Synthetic

Molecular formula :

C29H29ClN4O5.

Effective Concentration :

1 nM - 1 µM.

Activity :

SR 48527, an analog of SR 48692, is a potent and selective antagonist of NTS1 receptors, shown to inhibit neurotensin-stimulated IP production with Ki of 24 nM1,2.

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>95%

CAS No :

156579-04-3

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(2S)-2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]-2-cyclohexylacetic acid.

more info or order :

Alomone Labs product webpage