SJM-3 | Alomone Labs S-215 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

SJM-3

catalog :

S-215

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs TTA-P2 (S-enantiomer) blocks T-type CaVchannels expressed inXenopusoocytes. - A. Time course of CaV3.2 peak current amplitude elicited by 100 ms voltage step from holding potential of -100 mV to -30 mV delivered every 10 seconds. Application of 5 MTTA-P2 (S-enantiomer)(#T-210) inhibits the CaV3.2 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 5 M TTA-P2 as indicated.

product information

CAT :

S-215

SKU :

S-215_10 mg

Product Name :

SJM-3

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

SJM-3 is a positive allosteric modulator of γ-aminobutyric acid type A (GABA(A)) receptors. It potentiates GABA(A) receptor currents by binding at the diazepam binding site in the transmembrane domain. SJM-3 was also shown to act as an antagonist at the α+/γ− site of the receptor1.GABA(A) receptors belong to the cys-loop pentameric ligand-gated ion channel family. These receptors are major inhibitory neurotransmitter receptors in the brain and in the mammalian central nervous system and are responsible for mediating GABA action. They are composed of five homologous subunits that are arranged around a central chloride-selective pore. GABA(A) receptors are important targets for many clinical drugs1,2.

Supplier :

Alomone Labs

Target :

GABA(A) receptors

Long Description :

SJM-3 (#S-215) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Positive Allosteric Modulator of GABA(A) Receptors

MW :

354.4

Source :

Synthetic

Molecular formula :

C18H15FN4OS.

Effective Concentration :

1-100 µM.

Activity :

SJM-3 is a novel positive allosteric modulator of GABA(A) receptors at the benzodiazepine modulatory site (pKi = 6.7), strongly potentiating GABA currents at 30 µM via the binding site for diazepam in the transmembrane domain, while acting as an antagonist at the α+/γ− site1.

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge before handling (10000 x g, 5 min).

Solubility :

Soluble in DMSO. Centrifuge before handling (10000 x g, 5 min).

Storage of solutions :

-20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>97%

CAS No :

1234977-97-9

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-yl)-(2-pyrazin-2-yl-1,3-thiazol-4-yl)methanone.

more info or order :

Alomone Labs product webpage