SNAP 37889 | Alomone Labs S-210 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

SNAP 37889

catalog :

S-210

more info or order :

Alomone Labs product webpage

product information

CAT :

S-210

SKU :

S-210_10 mg

Product Name :

SNAP 37889

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

SNAP 37889 is a potent and selective Galanin 3 receptor (GalR3) antagonist. The compound exists as E- and Z-isomers that interconvert quickly in solution at room temperature1,2.Studies conducted in animals show that acute administration of SNAP 37889 enhances rat social interaction, reduces guinea pig vocalizations after maternal separation, and attenuates stress-induced hyperthermia in mice1.Galanin is a widely distributed neuropeptide that regulates various endocrine, pain and cognitive functions, including learning and memory in the central nervous system (CNS). It activates one of three receptors belonging to the GPCR superfamily: GalR1, GalR2 and GalR3. GAL3 receptors are involved in anxiety, depression, and drug-seeking behavior1,2.

Supplier :

Alomone Labs

Target :

Galanin 3 receptor

Long Description :

SNAP 37889 (#S-210) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Selective Antagonist of Galanin 3 Receptor

MW :

366.34

Synonyms :

HT-2157

Source :

Synthetic

Molecular formula :

C21H13F3N2O.

Effective Concentration :

10 nM - 10 µM.

Activity :

SNAP 37889 is a potent GalR3 galanin receptor antagonist, highly selective for GalR3 (Ki = 17.44 nM) over GalR1 and GalR2 (Ki > 10 µM), showing anxiolytic and antidepressant-like effects in rodent models in vivo1-2.

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).

Solubility :

Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).

Storage of solutions :

Up to three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

303149-14-6

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one.

more info or order :

Alomone Labs product webpage