SB-366791 | Alomone Labs S-180 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

SB-366791

catalog :

S-180

more info or order :

Alomone Labs product webpage

image

image 1 :

Peptide (C)RQPSSPGPQPRNLSE corresponding to amino acid residues 191-205 of mouse ?1-syntrophin (AccessionQ61234). Intracellular PH1 domain.

product information

CAT :

S-180

SKU :

S-180_10 mg

Product Name :

SB-366791

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

SB-366791 is a potent and selective TRPV1 channel antagonist1. Novel strategies for the treatment of bone cancer pain have shown that morphine in combination with SB-366791 has potent analgesic effects on bone cancer pain2.TRPV1 (Vanilloid receptor-1) is a member of a distinct subgroup of transient receptor potential (TRP) family. These channels are highly expressed on primary nociceptors. TRPV1 can be activated by several different stimuli such as heat, acid, certain arachidonic acid derivatives and direct phosphorylation via PKC. TRPV1 may serve a central role in inflammatory nociception3.Studies have shown that local intradermal treatment with SB-366791 compound has the ability to reduce thermal hyperalgesia and mechanical allodynia without affecting mechanical hyperalgesia4.

Supplier :

Alomone Labs

Target :

TRPV1 channels

Long Description :

SB-366791 (#S-180) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Specific and Potent TRPV1 Blocker

MW :

287.7

Source :

Synthetic

Molecular formula :

C16H14ClNO2.

Effective Concentration :

5 nM - 50 µM.

Activity :

SB-366791 is a TRPV1 channel antagonist1.

Reconstitution and Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

472981-92-3

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide.

more info or order :

Alomone Labs product webpage