chemical

SB-705498

S-160

S-160_10 mg

SB-705498

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

SB-705498 is a specific and potent antagonist for TRPV1. Generally, TRPV1 inhibitors are classified as either both capsaicin and proton blockers, and mainly capsaicin blockers. SB-705498 belongs to the first class2. After experimenting with lesser potent and effective antagonists, the major advantageous modification the compound's developers had introduced into the related TRPV1 archetypal inhibitors was a trifluoromethyl-substituted pyridine ring; it presented SB-705498 with good solubility and oral bioavailability, superior pharmacokinetic properties1-3.SB-705498 was developed as an intranasal medication for the treatment of neuropathic and inflammatory pain. Recent clinical trials checked the effectiveness of the compound in treating rhinitis, alleviating dental pain, and relieving acute migraine headache2,4.

Alomone Labs

TRPV1 channels

SB-705498 (#S-160) is a highly pure, synthetic, and biologically active compound.

A Blocker of TRPV1 Channels

428.05

Synthetic

C17H16BrF3N4O.

10 nM - 50 µM.

SB-705498 is a potent orally active TRPV1 blocker1.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity

DMSO 100 mM. Centrifuge all product preparations before use (10000 x g 1 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

501951-42-4

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

(R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)ureaN-(2-bromophenyl)-N?-[((R)-1-(5-trifluoromethyl-2-pyridyl)pyrrolidin-3-yl)]urea.