chemical

RJR 2403 oxalate

R-115

R-115_10 mg

RJR 2403 oxalate

Non Antibodies

S. Molecules

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Neuronal nAChRs are a larger family of ligand-gated ion channels widely expressed in both the central and the peripheral nervous systems. At least 12 different subunits of nAChRs, including α2-α10, β2-β4, have been identified so far and these subunits form many different sub- types of nAChRs with pentameric structures consisting of homomers or heteromers1. It has been shown that nAChRs are involved in a variety of physiological functions including learning, reinforcement, development, aging and nociception2.RJR-2403 [(E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine or metanicotine] is a potent and effective activator of human α4/β2 receptors with a significant selectivity for this receptor subtype (EC50 value = 16 μM)3. RJR-2403 exhibits potency and selectivity for CNS nAChRs thought to play a role in various CNS disorders3. Functional studies show that RJR-2403 is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 nM for RJR-2403 and EC50 = 591 nM for nicotine)4.

Alomone Labs

α4/β2 nAChRs

RJR 2403 oxalate (#R-115) is a highly pure, synthetic, and biologically active compound.

An Agonist of α4/β2 nAChRs

252.3

Rivanicline oxalate

Synthetic

C12H16N2O4.

1-100 µM.

RJR 2403 oxalate activates α4/β2 nAChR EC50 ~ 16 μM1.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity

Water. Centrifuge all product preparations before use (10000 x 1 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

220662-95-3

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

(E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate.