chemical

QX-222 chloride

Q-200

Q-200_10 mg

QX-222 chloride

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

QX-222 is a quarternary derivative of the local anesthetic Lidocaine. It was shown to block NaV currents and channels in a use-dependent manner.1 The blocking mechanism involves an intracellular binding site, but some NaV channels facilitate the passage of QX-222 via the open channel.2 In addition it was shown to inhibit nicotinic ACh receptor channels.3

Alomone Labs

Various NaV Na+ channels

QX-222 chloride (#Q-200) is a highly pure, synthetic, and biologically active compound.

A Blocker of NaV Channels

256.77 (as net anhydrous)

Synthetic

C13H21N2OCl.

0.5-10 mM.

QX-222 chloride blocks NaV currents1 and also inhibits nicotinic ACh receptor channels2.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity

Water. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or six months at -20°C. Protect from light. Hygroscopic.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

21236-55-5

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

2-[(2,6-Dimethylphenyl)amino]-N,N,N-trimethyl-2-oxoetha niminium chloride.