Quin-C7 | Alomone Labs Q-155 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Quin-C7

catalog :

Q-155

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone LabsLosartan potassiuminhibits the activation of AT1R expressed in CHO-K1-mt aequorin-G?16 cells. - Dose-response curve for the inhibition of AT1R expressed in CHO-K1-mt aequorin-G?16 cells. Ca2+response as detected by elevation in aequorin derived fluorescence following 0.04 nM Angiotensin II application was inhibited by increasing concentrations ofLosartan potassium(#L-185). 20 nM Losartan potassium fully inhibited the activation by Angiotensin II.

image 2 :

product information

CAT :

Q-155

SKU :

Q-155_10 mg

Product Name :

Quin-C7

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Quin-C7 is a synthetic quinazolinone derivative that acts as a nonpeptide antagonist of human formyl peptide receptor like 1 (FPRL1, FPR2)1. Quin-C7 can partially displace [(125)I]Trp-Lys-Tyr-Met-Val-d-Met-NH(2) (WKYMVm) binding to FPRL1 receptor1.The formyl peptide receptors include the FPR1, FPR2, and FPR3. FPR2 is primarily expressed in neutrophils and monocytes where it plays an important role in inflammation and in the immune system1,2.

Supplier :

Alomone Labs

Target :

FPR2 receptors

Long Description :

Quin-C7 (#Q-155) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of FPR2 Receptor

MW :

431.49

Synonyms :

4-butoxy-N-[2-(4-hydroxyphenyl)-4-oxo-1,2-dihydroquinazolin-3-yl]benzamide

Source :

Synthetic

Molecular formula :

C25H25N3O4.

Effective Concentration :

100 µM.

Activity :

Quin-C7 is a nonpeptide antagonist of N-formyl peptide receptor 2 (FPR2, FPRL1), shown to partially displace [125I]WKYMVm from FPR2 receptors, and inhibit WKYMVm-induced calcium mobilization and chemotaxis at 100µM1.

Reconstitution and Solubility :

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.

Solubility :

Soluble up to 100 mM in DMSO. Spin down all products before handling.

Storage of solutions :

Store at -20°C for several months. It is recommended to aliquot stock solutions to avoid repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>96%

CAS No :

871100-12-8

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

4-butoxy-N-[2-(4-hydroxyphenyl)-4-oxo-1,2-dihydroquinazolin-3-yl]benzamide.

more info or order :

Alomone Labs product webpage