chemical

Ochratoxin A

O-400

O-400_0.5 mg

Ochratoxin A

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Ochratoxin A is a natural metabolic alkaloid produce by Aspergillus ochraceus1. Ochratoxin A is a potent a toxin which causes nephrosis in mammals. In the circulation, Ochratoxin A has a very long half-life in all species examined2. Although the kidney is the primary target organ for Ochratoxin A activity, studies indicate that Ochratoxin A is also a liver toxin, immunosuppressant, potent teratogen, and carcinogen3. Ochratoxin A increases activity of the endoplasmic reticulum ATP-dependent Ca2+ pump4.

Alomone Labs

SERCA pump

Ochratoxin A (#O-400) is a highly pure, natural, and biologically active compound.

A Potent Modulator of Ca2+ ATPase Pump

403.8

Natural

C20H18ClNO6.

100 nM - 1 μM.

Ochratoxin A causes an increase in ATP-driven Ca2+ pump activity in the ER1. Ochratoxin A also induces apoptosis in a JNK-dependent fashion2.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Methanol. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.Protect from light.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

303-47-9

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

(-)-N-((5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenylalanine.