NAX-5055 | Alomone Labs N-360 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

NAX-5055

catalog :

N-360

more info or order :

Alomone Labs product webpage

image

image 1 :

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product information

CAT :

N-360

SKU :

N-360_10 mg

Product Name :

NAX-5055

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Product Page - Scientific background :

NAX-5055 is an active analog of the endogenous neuropeptide galanin that acts as a galanin receptor 1 (GalR1) and galanin receptor 2 (GalR2) agonist. NAX-5055 demonstrates high affinity for the receptors and was shown to prevent seizures in mouse model of epilepsy following intraperitoneal administration1.NAX-5055 is a systemically-active, metabolically stable galanin analog that can penetrate the blood-brain-barrier and displays a potent anticonvulsant activity2,3.Galanin is widely expressed throughout the central and peripheral nervous systems. Galanin receptors belong to the family of G-protein coupled receptors. Studies show that galanin and its receptors are involved in the transmission and modulation of nociception in the central nervous system, at spinal cord levels and in the brain4.

Supplier :

Alomone Labs

Target :

Galanin Receptors

Long Description :

NAX-5055 (#N-360) is a highly pure, synthetic, and biologically active modified peptide.

Short Description :

An Agonist of GalR1 and GalR2 Galanin Receptors

MW :

2112.6 Da

Synonyms :

Gal-B2

Modifications :

N-terminal glycine is substituted with sarcosine. Lys at position 16 is palmitoylated. C-terminal amidation.

Molecular formula :

C104H174N24O22.

Effective Concentration :

1-100 nM.

Activity :

NAX-5055, a systemically active analogue of the endogenous neuropeptide galanin, is a high affinity galanin receptors ligand (Ki=3.5 nM and 51.5 nM for GalR1 and GalR2, respectively), shown to prevent seizures in mouse epilepsy model in vivo1,2.

Solubility :

Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).

Storage of solutions :

Up to three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98% (HPLC)

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

sequence :

(Sar)WTLNSAGYLLGPKKK(pal)K-NH2.

UNSPSC :

41116134

Bioassay Tested :

Yes

more info or order :

Alomone Labs product webpage