chemical

N-Me-aminopyrimidinone 9

N-310

N-310_10 mg

N-Me-aminopyrimidinone 9

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

N-Me-aminopyrimidinone 9, is a synthetic blocker of NaV1.7 channel. It has an effective concentration of 10 nM - 1 μM and an IC50 of 100 nM for NaV1.7 channel in its inactive state.NaV channels contribute to physiological and pathophysiological electrical signaling in nerve and muscle cells. NaV1.7 is highly expressed on the exons somatic afferent neurons and is thought to play an important role in the signaling of inflammatory pain.

Alomone Labs

NaV1.7 channels

N-Me-aminopyrimidinone 9 (#N-310) is a highly pure, synthetic, and biologically active compound.

A Specific Blocker of NaV1.7 Channel

303.4

Synthetic

C16H21N3OS.

10 nM - 1 µM.

N-Me-aminopyrimidinone 9 is a NaV1.7 channel blocker with IC50 value of 100 nM for NaV1.7 channels in their inactivated state1.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

1356834-62-2

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

6-amino-2-[(4-tert-butylphenyl)methylsulfanyl]-3-methylpyrimidin-4-one.