NS19504 | Alomone Labs N-235 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

NS19504

catalog :

N-235

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Huang S, Chen T, Suo Q, Shi R, Khan H, Ma Y, et al. BK Channel-Mediated Microglial Phagocytosis Alleviates Neurological Deficit After Ischemic Stroke. Front Cell Neurosci. 2021;15:683769 pubmed publisher

image

image 1 :

Alomone LabsNS19504enhances KCa1.1 channels expressed inXenopusoocytes. - A. Time course of KCa1.1 channel activity at 55 mV demonstrating the effect of 10 and 50 ?MNS19504(#N-235). B. Representative current traces under control conditions and following application of 10 and 50 ?M NS19504. Currents were elicited by a 100 ms voltage ramp from -80 to 80 mV every 10 seconds from a holding potential of -100 mV (current responses are shown between -40 and 80 mV).

product information

CAT :

N-235

SKU :

N-235_10 mg

Product Name :

NS19504

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

NS19504 is a potent and selective activator of the large-conductance Ca2+-activated K+ channel, BKCa (KCa1.1). It activates heterologously expressed and native BK channels in a concentration-dependent manner with an EC50 value of 11.0 ± 1.4 µM1.Several researches have indicated that NS19504 could reduce nonvoiding contractions associated with spontaneous bladder overactivity while having a minimal effect on voluntary bladder emptying.BKCa channels are important regulators of urinary bladder function and may be used as an attractive therapeutic target in bladder disorders1.The large conductance Ca2+-activated K+ channels play a role in controlling the cell volume, they affect the driving force for Ca2+ influx and thus exert a secondary control on cell migration through regulation of Ca2+ signals by modulating the membrane potential2.

Supplier :

Alomone Labs

Target :

KCa1.1 K+ channels

Long Description :

NS19504 (#N-235) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Opener of KCa1.1 Channels

MW :

269.2

Source :

Synthetic

Molecular formula :

C10H9BrN2S.

Effective Concentration :

5 µM - 100 µM.

Activity :

NS19504 is a KCa1.1 channel opener1.

Reconstitution and Solubility :

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

327062-46-4

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

5-[(4-bromophenyl)methyl]-1,3-thiazol-2-amine.

more info or order :

Alomone Labs product webpage