chemical

NS-6180

N-230

N-230_10 mg

NS-6180

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

The benzothiazinone NS-6180 is a potent and selective KCa3.1 channel blocker1.The Ca2+-activated K+ channel, KCa3.1, plays a major role in the controlled expression of essential genes orchestrating proliferation, migration and cytokine production by participating in the regulation of calcium entry. A highly regulated and sustained increase in cytosolic Ca2+ is critical in these processes thus, the KCa3.1 channel is a potential target for therapy of immune disease1.Inhibition of KCa3.1 channel by NS-6180 demonstrates IC50 value of 14 nM in human, 9 nM in rat and 15 nM in mouse. NS6180 also has the ability to inhibit KCa1.1, KV1.3 and KV11.1 channels with IC50s above 10 µM2.

Alomone Labs

KCa3.1 channels

NS-6180 (#N-230) is a highly pure, synthetic, and biologically active compound.

A Potent Blocker of KCa3.1 Channel

323.3

Synthetic

C16H12F3NOS.

10 nM - 1 μM.

NS-6180 blocks SK4 channels with IC50 of 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively1.

100mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

100mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

353262-04-1

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

4-[[3-(Trifluoromethyl)phenyl]methy