Nonivamide | Alomone Labs N-220 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Nonivamide

catalog :

N-220

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs Nonivamideactivates TRPV1 channels heterologously expressed in C-6 cells. - Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+were detected. Normalized fluorescence before (control gray dotted line) and after application of 0.1 1 and 10 MNonivamide(#N-220) (as indicated).

product information

CAT :

N-220

SKU :

N-220_1 g

Product Name :

Nonivamide

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Nonivamide is a synthetic analog of capsaicin, a pungent ingredient in chili peppers. It binds to TRPV1 channel and activates it with high potency (EC50 ≈ 10-7 M). Treatment with nonivamide activates TRPV1 channels, allowing non-selective cation flux into neurons, causing membrane depolarization and increase in cytosolic Ca2+ due to release of Ca2+ from the endoplasmic reticulum1.TRPV1 is a member of the TRP family of ion-channels and found throughout the body in epithelial cells and in peripheral and central terminals in neurons. The TRPV family includes six mammalian ion channels, TRPV1-TRPV6. TRPV1 is a Ca2+-permeable channel which is activated and modulated by a variety of exogenous stimuli such as heat, changes in pH, and irritant and pungent compounds and by selected molecules released during inflammatory processes and tissue damage2.

Supplier :

Alomone Labs

Target :

TRPV1 channels

Long Description :

Nonivamide (#N-220) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent Activator of TRPV1 Channels

MW :

293.4

Synonyms :

Pelargonic acid vanillylamide/PAVA

Source :

Synthetic

Molecular formula :

C17H27NO4.

Effective Concentration :

100 nM - 10 µM.

Activity :

Nonivamide is a TRPV1 activator1.

Reconstitution and Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

2444-46-4

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide.

more info or order :

Alomone Labs product webpage