NS8593 hydrochloride | Alomone Labs N-195 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

NS8593 hydrochloride

catalog :

N-195

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Wang F, Li A, Meng T, Wang L, Wang L, Hou Y, et al. Regulation of [Ca2+]i oscillations and mitochondrial activity by various calcium transporters in mouse oocytes. Reprod Biol Endocrinol. 2020;18:87 pubmed publisher

image

image 1 :

Alomone Labs NS8593 HCl blocks KCa2.2 (SK2) currents expressed in HEK 293T cells. - A. Time course of KCa2.2 current amplitude and its blockade by 2 and 10 MNS8593 hydrochloride(#N-195). Currents were elicited by application of voltage ramp from a holding potential of -100 mV to +60 mV (150 msec) delivered every 10 seconds. B: Superimposed example traces of current responses before and during perfusion of 2 and 10 M NS8593 hydrochloride as indicated.

product information

CAT :

N-195

SKU :

N-195_10 mg

Product Name :

NS8593 hydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

NS8593 inhibits the gating modulation of all SK, small conductance Ca2+-activated K+ channels (KCa2.1, KCa2.2, KCa2.3) and blocks SK3 channels with an IC50 of 104 nM1,2. It does so by shifting the apparent Ca2+-dependence to higher Ca2+ concentrations2. NS8593 has no effect on other KCa channels1.NS8593 was also found to block TRPM7 currents with an IC50 value of 1.6 μM.

Supplier :

Alomone Labs

Target :

SK K+ channels, TRPM7

Long Description :

NS8593 hydrochloride (#N-195) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Blocker of KCa2 and TRPM7 Channels

MW :

299.79

Source :

Synthetic

Molecular formula :

C17H18ClN3.

Effective Concentration :

100 nM -10 µM.

Activity :

NS8593 is KCa2 (SK) channel blocker, with no activity towards KCa3.1 channels, with IC50~100 nM1,2. It also blocks TRPM7 channels3.

Reconstitution and Solubility :

50 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

50 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

875755-24-1

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine;hydrochloride.

more info or order :

Alomone Labs product webpage