(-)-Nicotine ditartrate | Alomone Labs N-175 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

(-)-Nicotine ditartrate

catalog :

N-175

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Collo G, Cavalleri L, Zoli M, Maskos U, Ratti E, Merlo Pich E. Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons. Front Pharmacol. 2018;9:572 pubmed publisher

image

image 1 :

Alomone Labs (-)-Nicotine ditartrate activates ?3/?4 nAChR heterologously expressed inXenopusoocytes. - A. Time course of current repetitive and reversible activation by 100 M(-)-Nicotine ditartrate(#N-175) applied by perfusion every 100 seconds in the presence of 3 MPNU 282987(#P-110). Holding potential was -80 mV.

image 2 :

Alomone Labs Flumazenil inhibits specific binding of Flunitrazepam to rat brain GABA(A) receptors. - Percent inhibition of specific binding of 1 nM [3H] Flunitrazepam to membranes from whole rat brain (except cerebellum) was plotted against concentrations ofFlumazenil(#F-145) (green circles) and of Diazepam (assay standard black squares) and used to calculate IC50and Ki values for Flumazenil (IC50? 7.35 nM and Ki ? 5.99 nM).

product information

CAT :

N-175

SKU :

N-175_1 g

Product Name :

(-)-Nicotine ditartrate

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

The nAChR complex, a cholinergic receptor, is composed of five subunits and is found in both the peripheral and central nervous systems. In the mammalian brain, there are as many as nine α subunits (α2 to α10) and three β subunits (β2 to β4). The most abundant receptor subtypes in the brains of humans are α4/β2, α3/β4, and α71.(-)-Nicotine ditartrate is a potent agonist of AChR. It stimulates autonomic ganglia and skeletal muscle neuromuscular junctions2. (-)-Nicotine ditartrate is a salt of nicotine of pharmaceutical grade and tartaric acid used for preparation of the products for smoking cessation and as an analytical standard3.

Supplier :

Alomone Labs

Target :

nAChR

Long Description :

(-)-Nicotine ditartrate (#N-175) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Agonist of nAChR

MW :

462.4

Source :

Synthetic

Molecular formula :

C18H26N2O12.

Effective Concentration :

0.5-200 µM.

Activity :

(-)-Nicotine ditartrate activates α7 nAChR with EC50 ~25 µM1.

Reconstitution and Solubility :

Water. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

Water. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

65-31-6

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt.

more info or order :

Alomone Labs product webpage