ML-301 | Alomone Labs M-315 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

ML-301

catalog :

M-315

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat liver lysate (lanes 1 and 4) mouse liver lysate (lanes 2 and 5) and rat kidney membranes (lanes 3 and 6): - 1-3. Anti-ENT3 (SLC29A3) Antibody(#ANT-053) (1:200).4-6. Anti-ENT3 (SLC29A3) Antibody preincubated with the negative control antigen.

product information

CAT :

M-315

SKU :

M-315_10 mg

Product Name :

ML-301

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

ML-301 is a fully selective imidazole-based agonist of neurotensin receptor 1 (NTR1). It stimulates NTR1-mediated calcium mobilization with an EC50 value of 289 nM1. The carboxylic acid moiety increases the compound's solubility1.To date, four neurotensin receptors have been cloned from human: NTR1, NTR2, NTR3 and NTR4 which belong to the super family of G-protein coupled receptors (GPCRs). NTR1 mediates most of the known neurotensin ligand effects and is a potential therapeutic target2.

Supplier :

Alomone Labs

Target :

Neurotensin Receptor 1

Long Description :

ML-301 (#M-315) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Selective Agonist of Neurotensin Receptor 1

MW :

522.99

Synonyms :

ML301

Source :

Synthetic

Molecular formula :

C27H27ClN4O5.

Effective Concentration :

1 nM - 1 µM.

Activity :

ML-301 is a selective agonist of NTR1 receptors, shown to stimulate NTR1-mediated calcium mobilization with EC50 of 289 nM1-2.

Reconstitution and Solubility :

Soluble in DMSO.Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble in DMSO.Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

Store at -20°C.It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

1531633-84-7

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2,6-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid.

more info or order :

Alomone Labs product webpage