ML133 hydrochloride | Alomone Labs M-275 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

ML133 hydrochloride

catalog :

M-275

more info or order :

Alomone Labs product webpage

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image 1 :

Alomone Labs Eliprodil inhibits specific binding of Ifenprodil to rat brain cortex NMDA receptors at polyamine sites. - Percent inhibition of specific binding of 2 nM [3H] Ifenprodil to membranes from rat brain cerebral cortex plotted against concentrations ofEliprodil(#E-155). Full inhibition is achieved at 3 M.

image 2 :

product information

CAT :

M-275

SKU :

M-275_10 mg

Product Name :

ML133 hydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

ML133 hydrochloride is a selective small molecule that acts as an inhibitor of Kir2 inward rectifier potassium channels. The compound blocks Kir2.1, Kir2.6, Kir2.2 and Kir2.3 and shows little or no effect on other Kir channels1. ML133 hydrochloride demonstrates IC50 values of 1.8, 2.8, 2.9 and 4.0 μM for Kir2.1, Kir2.6, Kir2.2 and Kir2.3, respectively at pH 7.41.Kir channels are a family of membrane proteins that selectively control the permeation of K+ ions across cell membranes. These channels play an important role in establishing the resting membrane potential of excitable cells, regulating pacing in cardiomyocytes and neurons, regulating pancreatic insulin secretion and renal K+ transport2.

Supplier :

Alomone Labs

Target :

Kir2 channels

Long Description :

ML133 hydrochloride (#M-275) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Selective Blocker of Kir2 Channels

MW :

313.82

Synonyms :

ML133 HCl, N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride

Source :

Synthetic

Molecular formula :

C19H19NO · HCl.

Effective Concentration :

1-20 µM.

Activity :

ML133 hydrochloride selectively inhibits Kir2 inward-rectifier potassium channels with IC50 values of 1.8, 2.8, 2.9 and 4.0 μM for Kir2.1, Kir2.6, Kir2.2 and Kir2.3, respectively (at pH 7.4), and with little or no effect on Kir4.1, Kir7.1 or Kir1.1 channels.1

Reconstitution and Solubility :

Soluble to 100 mM in DMSO. Spin down all products before handling.

Solubility :

Soluble to 100 mM in DMSO. Spin down all products before handling.

Storage of solutions :

Store at -20°C for several months. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>97%

CAS No :

1222781-70-5

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1-(4-methoxyphenyl)-~{N}-(naphthalen-1-ylmethyl)methanamine; hydrochloride.

more info or order :

Alomone Labs product webpage