2'MeO6MF | Alomone Labs M-245 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

2'MeO6MF

catalog :

M-245

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs Ganaxolone inhibits specific binding of TBPS to rat brain cortex GABA(A) receptors. - Percent inhibition of specific binding of 2 nM [35S] TBPSto membranes from rat brain cerebral cortex was plotted against concentrations ofGanaxolone(#G-120) (green circles) and of Picrotoxin (assay standard black squares) and used to calculate IC50and Ki values for Ganaxolone (IC50? 0.81 M and Ki ? 0.79 M).

image 2 :

product information

CAT :

M-245

SKU :

M-245_10 mg

Product Name :

2'MeO6MF

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

2'MeO6MF is a synthetic compound that acts as a potentiator of GABA(A) receptors. Studies show that the compound can directly activate α2β2/3 and α2β2/3γ2L receptor subtypes without modulating the effect of GABA. 2'MeO6MF was shown to potentiate the response to GABA in Xenopus oocytes with EC50 values ranging from 21 µM to 98 µM, depending on subunit combination1.2'MeO6MF is a useful tool for studying the complex nature of the activation and modulation of GABA(A) receptor subtypes1,2.At high dosage, 2'MeO6MF induces sedative effects, and anxiolytic effects at low doses1.GABAA receptors belong to the pentameric Cys-loop superfamily of ligand-gated ion channel receptors and are physiologically significant in the central nervous system. GABA(A) receptors are the site of action for many clinically-relevant chemicals including benzodiazepines, barbiturates and anaesthetics1,2.

Supplier :

Alomone Labs

Target :

GABA(A) receptors

Long Description :

2'MeO6MF (#M-245) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potentiator of GABA(A) Receptors

MW :

266.3

Synonyms :

2'-Methoxy-6-methylflavone

Source :

Synthetic

Molecular formula :

C17H14O3.

Effective Concentration :

10-100 µM.

Activity :

2'MeO6MF is a GABAA receptor modulator, shown to potentiate the response to GABA (EC10) with EC50 ranging from 21 µM to 98 µM, depending on subunit combination, in Xenopus oocytes. Displays anxiolytic-like and sedative effects in mice1.

Reconstitution and Solubility :

Soluble up to 100 mM in DMSO. Spin down all products before handling.

Solubility :

Soluble up to 100 mM in DMSO. Spin down all products before handling.

Storage of solutions :

Store at -20°C for several months. It is recommended to aliquot stock solutions to avoid repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>95%

CAS No :

89112-85-6

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-(2-methoxyphenyl)-6-methylchromen-4-one.

more info or order :

Alomone Labs product webpage