product summary
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company name :
Alomone Labs
product type :
chemical
product name :
(+)-MK 801 maleate
catalog :
M-230
more info or order :
citations: 2
Reference |
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Postnikova T, Griflyuk A, Ergina J, Zubareva O, Zaitsev A. Administration of Bacterial Lipopolysaccharide during Early Postnatal Ontogenesis Induces Transient Impairment of Long-Term Synaptic Plasticity Associated with Behavioral Abnormalities in Young Rats. Pharmaceuticals (Basel). 2020;13: pubmed publisher
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product information
CAT :
M-230
SKU :
M-230_10 mg
Product Name :
(+)-MK 801 maleate
Group Type :
Non Antibodies
Product Type :
S. Molecules
Storage After Reconstitution :
The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Shipping and storage :
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Product Page - Scientific background :
MK-801 maleate is a non competitive, high affinity, open channel blocker of the N-methyl-D-aspartate (NMDA) receptors. MK-801 blocks NMDA-induced currents in a voltage-dependent manner, preventing the influx of calcium ions through the channel. This compound is being used as a pharmacological tool to explore NMDA receptor function.The drug exists in two isomers (+) and (-) and displays several biological properties such as anticonvulsant and anesthetic. MK-801 is not used clinically because it has been shown to promote the development of brain lesions in rats1,2.NMDA receptors are ion channels gated by the major excitatory neurotransmitter in the mammalian central nervous system, glutamate. Glutamate-mediated signaling is important for basic neuron-to-neuron signaling and neuronal processes such as learning, memory and pain perception3.In rats, MK-801 has the ability to induce a characteristic behavioral syndrome with ataxia, stereotypic behavior and hyperlocomotion. In addition, the compound can induce necrosis in a small population of neurons in the cortex of rats4.It has also been discerned that MK-801 induces schizophrenia-like symptoms in rodents, including cognitive functions5.
Supplier :
Alomone Labs
Target :
NMDA receptors
Long Description :
(+)-MK 801 maleate (#M-230) is a highly pure, synthetic, and biologically active compound.
Short Description :
An Antagonist of NMDA Receptors
MW :
337.4
Synonyms :
Dizocilpine hydrogen maleate
Source :
Synthetic
Molecular formula :
C20H19NO4.
Effective Concentration :
0.01-10 µM.
Activity :
(+)-MK 801 maleate is a potent, selective and non-competitive NMDA receptor antagonist with an IC50 of 0.01 μM1.
Reconstitution and Solubility :
Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Solubility :
Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Storage of solutions :
Up to four weeks at 4°C or three months at -20°C.
Lead Time :
1-2 Business Days
Country of origin :
Israel/IL
Applications key :
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Purity :
>99% (HPLC)
CAS No :
77086-22-7
Form :
Lyophilized powder.
Comment :
Contact Alomone Labs for technical support and product customization
UNSPSC :
41116134
Bioassay Tested :
Yes
Chemical Name :
(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate.
more info or order :
company information

Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com972 2 531 8002
headquarters: Israel
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