MCI-225 | Alomone Labs M-190 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

MCI-225

catalog :

M-190

more info or order :

Alomone Labs product webpage

product information

CAT :

M-190

SKU :

M-190_10 mg

Product Name :

MCI-225

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

MCI-225 is a psychoactive compound, a thienopyrimidine analogue that acts as a selective noradrenaline (NA) reuptake inhibitor with 5-HT3 channel blocking action. The compound demonstrates antidepressant-like activity with primary activity in the central nervous system.Several studies have shown that MCI-225 exhibits improvement in amnesia in scopolamine treated rats and in basal forebrain lesion rats. Acute administration of MCI-225 inhibits the rise of threshold induced by footshock stress1.It has been suggested that MCI-225 may affect attention, learning and memory2.

Supplier :

Alomone Labs

Target :

5-HT3A receptor, NET transporter

Long Description :

MCI-225 (#M-190) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent Antagonist of 5-HT3 Channels and a Selective Noradrenaline Reuptake Inhibitor

MW :

328.4

Synonyms :

DDP-225

Source :

Synthetic

Molecular formula :

C17H17FN4S.

Effective Concentration :

10 nM - 1 µM.

Activity :

MCI-225 shows high affinity for the 5-HT3 receptor, Ki less than 100 nmol/L1.

Reconstitution and Solubility :

30 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

30 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

135991-48-9

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

4-(2-fluorophenyl)-6-methyl-2-piperazin-1-ylthieno[2,3-d]pyrimidine.

more info or order :

Alomone Labs product webpage