ML 218 hydrochloride | Alomone Labs M-166 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

ML 218 hydrochloride

catalog :

M-166

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs ML 218 hydrochloride inhibits T-type CaVchannels heterologously expressed inXenopusoocytes. - A. Time course of CaV3.2 peak current amplitude elicited by 100 ms voltage step from holding potential of -100 mV to -30 mV delivered every 10 seconds. Application of 2 MML 218 hydrochloride(#M-166) inhibits the CaV3.2 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 2 M ML 218 hydrochloride as indicated.

image 2 :

Peptide (C)DVEFSFPKFSRLRR corresponding to amino acid residues 155-170 of rat PRX (AccessionQ63425). Intracellular N-terminus.

product information

CAT :

M-166

SKU :

M-166_10 mg

Product Name :

ML 218 hydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

T-Type Ca2+ channel inhibitors hold tremendous therapeutic potential for the treatment of pain, epilepsy, sleep disorders, essential tremor, and other neurological disorders1. ML 218 is a selective, potent inhibitor of T-type Ca2+ channels (IC50 values are 270 and 310 nM for CaV3.3 and CaV3.2 respectively in a patch EP assay). It has no activity on other members of the Ca2+ family of ion channels (L- and N-type Ca2+ channels) as well as multiple Na+ and K+ channels. ML 218 was found to be non-selective against hERG and many other ion channels. ML 218 possess excellent DMPK properties, acceptable in vivo rat PK, excellent brain levels and was efficacious in a haloperidol-induced catalepsy assay, a preclinical Parkinsonian model. ML 218 decreases burst activity in subthalamic nucleus (STN) neurons. Thus, ML 218 is a powerful new probe to study T-Type Ca2+ function both in vitro and in vivo2.

Supplier :

Alomone Labs

Target :

T-type CaV channels

Long Description :

ML 218 hydrochloride (#M-166) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Selective Blocker of T-type Channels

MW :

405.8

Synonyms :

MLS003431854, SMR002112449, VU0413807-1, VU0413807-2, VU0424199-1

Source :

Synthetic

Molecular formula :

C19H26Cl2N2O•HCl.

Effective Concentration :

0.1-100 µM.

Activity :

ML 218 is a blocker of T-type Ca2+ channels (IC50 values are 270 and 310 nM for CaV3.3 and CaV3.2 respectively)1.

Reconstitution and Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

1346233-68-8

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride.

more info or order :

Alomone Labs product webpage