chemical

MDL 72222

M-155

M-155_10 mg

MDL 72222

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.MDL 72222 (Bemesetron) is a synthetic, potent and selective antagonist of the 5-HT3 receptor. MDL 72222 has an effective concentration of 1 nM - 1μM and an ED50 of 9.27 nM. MDL 72222 produces blockade of the Bezold-Jarisch effect of 5-HT in anaesthetized rats. Inhibition of the 5-HT receptor by MDL 72222 is selective since high doses of MDL 72222 fail to alter response to electrical stimulation of efferent vagus nerves. In contrast, MDL 72222 proves only a weak and essentially non-selective antagonist of responses mediated by the 5-HT M-receptor present on the cholinergic nerves of guinea-pig ileum. MDL 72222 does not block smooth muscle contractile responses elicited by oxytocin or mediated through 5-HT D-receptors2. In addition, MDL 72222 also significantly reduces pancreatic enzyme secretion induced by luminal administration of L-trp or melatonin and reverses the effects of 5-HT on amylase secretion3.

Alomone Labs

5-HT3 receptor

MDL 72222 (#M-155) is a highly pure, synthetic, and biologically active compound.

An Antagonist of 5-HT3 Receptors

314.2

3-Tropanyl-3,5-dichlorobenzoate, Bemesetron, MDL 72699

Synthetic

C15H17Cl2NO2.

1 nM - 1µM.

MDL 72222 is an antagonist of 5-HT3 receptors1.

25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>95%

40796-97-2

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3,5-dichlorobenzoate.