L-Quisqualic acid | Alomone Labs L-210 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

L-Quisqualic acid

catalog :

L-210

more info or order :

Alomone Labs product webpage

image

image 1 :

product information

CAT :

L-210

SKU :

L-210_1 mg

Product Name :

L-Quisqualic acid

Group Type :

Non Antibodies

Product Type :

S. Molecules

Accession :

https://www.uniprot.org/uniprotkb/P23631/entry

Storage After Reconstitution :

Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Glutamate is the main excitatory neurotransmitter in the CNS and is also involved in a variety of pathological conditions. AMPA-type glutamate receptors are tetrameric ion channels that mediate fast excitatory synaptic transmission in the mammalian brain.L-Quisqualic acid (Quisqualate) is a selective agonist of AMPA receptors. Quisqualate binds to the AMPA receptor subunit GluR2 at the base of a deep cleft between two globular domains (GluR2-S1S2) causing the translation and rotation of domain S2 so that the cleft closes. The rate in which quisqualate dissociates from the AMPA receptor is primarily determined by the rate at which the receptor's binding domain opens. Mutations that destabilize the closed-cleft conformation of the receptor increase the rate of quisqualate dissociation and alter its relative efficacy1. Interestingly, although glutamate is known to cause an increase in human melanoma cell viability quisqualate does not create a similar effect even though it stimulates PI hydrolysis, thus suggesting it is a "G-protein biased agonist"2.

Supplier :

Alomone Labs

Target :

AMPA receptors

Long Description :

L-Quisqualic acid (#L-210) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Agonist of AMPA Receptors

MW :

189.1

Synonyms :

Quisqualate, (+)-Quisqualic acid

Source :

Synthetic

Molecular formula :

C5H7N3O5.

Effective Concentration :

0.01-100 µM.

Activity :

L-Quisqualic acid is a selective AMPA receptor agonist1.

Reconstitution and Solubility :

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. Soluble in water. Once dissolved in water, add an equal volume of glycerol. Do not shake or vortex. Avoid multiple freeze-thawing cycles

Solubility :

20 mM in H2O. Centrifuge all product preparations before use (10 000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

0.98

CAS No :

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Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid.

more info or order :

Alomone Labs product webpage