chemical

L-701,324

L-195

L-195_10 mg

L-701,324

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Glutamate is a central excitatory neurotransmitter in the nervous system and his mediating signaling is important for basic neuron-to-neuron signaling and neuronal processes such as learning, memory and pain perception. N-methyl-D-aspartate (NMDA) receptor are the major subtype of glutamate receptors that participate in synaptic transmission. NMDA receptor consists of three different subunits termed GluN1-3. Activation of NMDA receptor carried out via interaction with glycine and glutamate1.L-701,324 (7-chloro-4-hydroxy-3(3-phenoxy) phenylquinoline-2-(H)-on) is an effective NMDA antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine binding site. It was found that L-701,324 when administered orally has an inhibitory effect on spreading depression (SD) initiations and propagation2. Moreover L-701,324 act as anticonvulsant and neuroprotective agent3. Recently it was shown that antidepressant effect of L-701,324 in mice IS mediated by elevating the hippocampal BDNF signaling cascade4.

Alomone Labs

NMDA receptor

L-701,324 (#L-195) is a highly pure, synthetic and biologically active compound.

An Antagonist of NMDA Receptors

363.8

7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone

Synthetic

C21H14CINO3

2 nM - 0.1 µM

L-701,324 is a potent and selective NMDA receptor antagonist that acts at the glycine site1,2.

Soluble in DMSO. It is recommended to prepare fresh solutions before use. Centrifuge all products before use (10000 x, g 5 min). Avoid multiple freezing and thawing.

Soluble in DMSO. It is recommended to prepare fresh solutions before use. Centrifuge all products before use (10000 x, g 5 min). Avoid multiple freezing and thawing.

Store up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>97%

142326-59-8

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone