chemical

LY278584

L-180

L-180_10 mg

LY278584

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

LY278584 is a potent and selective antagonist of 5-HT3 receptors. Its structure is very similar to granisetron, also a 5-HT3 receptor antagonist. LY278584 is a useful ligand for studying the localization of 5-HT3 receptors in rat brain1,2.Numerous studies have shown that 5-HT3 antagonism is able to modulate mesolimbic dopaminergic activity in rodents. There is evidence that blockade of 5-HT3 receptors may be involved in nociception. Another study conducted on 5-HT3 antagonism showed that LY278584 significantly inhibits high frequency electroacupuncture antinociception in early stages3.The 5-HT3 receptors mediate the action of serotonin in the body. These receptors are members of the Cys-loop ligand-gated cation channels, which are expressed throughout the central and peripheral nervous systems and mediate a variety of physiological functions such as emotion, cognition, memory, pain perception, and gastrointestinal functions including secretion and motility4.

Alomone Labs

5-HT3 receptors

LY278584 (#L-180) is a highly pure, synthetic, and biologically active compound.

A Potent Antagonist of 5-HT3 Receptors

298.38

Synthetic

C17H22N4O.

1 nM - 1 µM.

LY278584 is a specifiic 5-HT3 antagonist. 0.1 μM completely blocks 1 μM 5HT evoked current in Xenopus oocytes1.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>97%

3970

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

1-methyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]indazole-3-carboxamide.