Lerisetron | Alomone Labs L-175 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Lerisetron

catalog :

L-175

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs Taurine inhibits specific binding of Strychnine to rat spinal cord Strychnine-sensitive Glycine receptors. - Percent inhibition of specific binding of 10 nM [3H]Strychnine to membranes from rat spinal cord was plotted against concentrations ofTaurine(#T-130) (green circles) and of (-)-Strychnine (assay standard black squares) and used to calculate IC50and Kivalues for Taurine (IC50? 397 M and Ki? 224 M).

product information

CAT :

L-175

SKU :

L-175_10 mg

Product Name :

Lerisetron

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Lerisetron, a piperazinylbenzimidazole derivative, is a potent and highly selective blocker of serotonin 5-HT3 channels with antiemetic effects. The drug is shown to be effective in the treatment of nausea and vomiting caused by emetogenic cytotoxic drugs1,2.Lerisetron antagonizes the serotonin action on the presynaptic 5-HT3 receptor that is implicated at the emetic reflex2,3.The 5-HT3 receptor mediates the action of serotonin in the body. This receptor is a member of the Cys-loop ligand-gated cation channels, which are expressed throughout the central and peripheral nervous systems and mediates a variety of physiological functions such as: emotion, cognition, memory, pain perception, and gastrointestinal functions including secretion and motility4.

Supplier :

Alomone Labs

Target :

5-HT3A receptors

Long Description :

Lerisetron (#L-175) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent Antagonist of 5-HT3 Channels

MW :

292.4

Source :

Synthetic

Molecular formula :

C18H20N4.

Effective Concentration :

0.5-100 nM.

Activity :

Lerisetron inhibits the 5-HT-induced Bezold-Jarisch reflex in anesthetized rats, pKi = 9.21.

Reconstitution and Solubility :

100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

143257-98-1

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1-benzyl-2-piperazin-1-ylbenzimidazole.

more info or order :

Alomone Labs product webpage