Linopirdine | Alomone Labs L-155 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Linopirdine

catalog :

L-155

more info or order :

Alomone Labs product webpage

citations: 2

Reference
Goff K, Goldberg E. Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome. elife. 2019;8: pubmed publisher
Paz R, Tubert C, Stahl A, Díaz A, Etchenique R, Murer M, et al. Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac. Neuropharmacology. 2018;137:309-321 pubmed publisher

image

image 1 :

Alomone Labs Linopirdine inhibits KCNQ2/KCNQ3 channels expressed inXenopusoocytes. - A. Time course of KCNQ2/KCNQ3 maximal current amplitude elicited by 700 ms voltage step from holding potential of -100 mV to -20 mV delivered every 10 seconds. Application of 300 MLinopirdine(#L-155) inhibits the KCNQ2/KCNQ3 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 300 M Linopirdine as indicated.

product information

CAT :

L-155

SKU :

L-155_10 mg

Product Name :

Linopirdine

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

KCNQ2 (KV7.2) and KCNQ3 (KV7.3) are voltage-gated K+ channel subunits that underlie the neuronal M current1. Linopirdine, a putative cognition enhancing drug, increases acetylcholine (ACh) release in rat brain tissue and improves performance in animal models of learning and memory. In addition to ACh, Linopirdine has been shown to enhance the in vitro release of dopamine and 5-hydroxytryptamine (5-HT), and, to a lesser extent, γ-aminobutyric acid and glutamate2. The enhanced release of one or more neurotransmitters may account for the activity linopirdine displays in behavioral models of learning and memory3. The mechanism whereby linopirdine enhances acetylcholine release has been proposed to involve inhibition of the M-type K+ current (IM). Linopirdine is selective for IM with an IC50 value of 2.4 μM2.

Supplier :

Alomone Labs

Target :

KCNQ K+ channels

Long Description :

Linopirdine (#L-155) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Blocker of KCNQ (KV7) Channels

MW :

391.46

Source :

Synthetic

Molecular formula :

C26H21N3O.

Effective Concentration :

0.1-300 µM.

Activity :

Linopirdine blocks KCNQ channels with an IC50 of 2.4 μM for KV7.2/3 heteromers1.

Reconstitution and Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

105431-72-9

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one.

more info or order :

Alomone Labs product webpage