Lomerizine dihydrochloride | Alomone Labs L-125 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Lomerizine dihydrochloride

catalog :

L-125

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs Lomerizine dihydrochloride inhibits L-type voltage-gated CaV1.2 currents heterologously expressed inXenopusoocytes. - A. Time course of CaV1.2/?2-?1/?2a (L-type) current inhibition by 10 and 100 MLomerizine dihydrochloride(#L-125). Currents were elicited by application of voltage steps from a holding potential of -100 mV to 0 mV (100 msec). B. Superimposed example traces of current responses before and during perfusion of 10 and 100 M Lomerizine dihydrochloride as indicated.

product information

CAT :

L-125

SKU :

L-125_1 g

Product Name :

Lomerizine dihydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Voltage-dependent L-type Ca2+ channels play an important role Ca2+ influx. L-type calcium currents typically require a strong depolarization for activation and are long-lasting1.The common pharmacological profile of L-type channels is determined by the α1 subunit, which forms the Ca2+ selective pore, and is encoded by one of the CaV1 (α 1S) channel genes2. Cav1.2 (CACNA1C) in humans is widely expressed in cardiac myocytes, smooth muscle myocytes, endocrine cells, neuronal cell bodies and proximal dendrites1.Lomerizine dihydrochloride is a Ca2+ channel blocker with relatively selective CNS effects. Lomerizine was developed as a potential agent for the selective improvement of the ocular or cerebrovascular circulation with minimal adverse cardiovascular effects3, and it is used as an anti migraine drug4. Lomerizine selectively relaxes smooth muscle cells by inhibiting L-type Ca2+ influx, thereby reducing tone and increasing blood flow in cerebral vessels4.Lomerizine blocked Ba2+ current through the voltage-gated Ca2+ channel in rat pheochromocytoma (PC12) cells5, and it is suggested to bind to the 1,4-dihydropyridine binding site, as obtained by a [3H]nitrendipine binding study6.

Supplier :

Alomone Labs

Target :

L-type Ca2+ channels

Long Description :

Lomerizine dihydrochloride (#L-125) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Blocker of L-Type Voltage-Gated Ca2+ Channels

MW :

541.5

Source :

Synthetic

Molecular formula :

C27H32N2F2O3Cl2.

Effective Concentration :

0.5-100 µM.

Activity :

Lomerizine dihydrochloride inhibited CaV currents in PC12 cells with IC50 of 1.9 µM1. It inhibits L-type Ca2+ channels2.

Reconstitution and Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

101477-54-7

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride.

more info or order :

Alomone Labs product webpage