Kainic acid monohydrate | Alomone Labs K-200 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Kainic acid monohydrate

catalog :

K-200

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs NS-11021 activatesKCa1.1 channels expressed inXenopusoocytes. - A. Time course of normalized KCa1.1 currents at +50 mV. Currents were elicited by 150 ms voltage ramp from holding potential of -100 mV to +100 mV every 10 sec.NS-11021(#N-335) applied at 2 M and 10 M as indicated (bars) reversibly enhanced KCa1.1 currents. B. Current traces upon application of control or of 2 M and 10 M NS-11021 (as indicated).

product information

CAT :

K-200

SKU :

K-200_10 mg

Product Name :

Kainic acid monohydrate

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Kainic acid is an analog of the excitotoxic neurotransmitter glutamate used as a selective agonist of Kainate receptors1,2.Studies show that treatment with Kainic acid may induce seizures leading to neuronal death and biochemical changes similar to those seen in human patients with temporal lobe epilepsy1. Kainic acid may induce apoptotic death of rat striatal neurons in an autophagic mechanism2. Several studies of rat model show progressive death of nigral neurons following unilateral injection of Kainic acid in the striatum3.Kainate-type glutamate receptors (KARs) are highly expressed in the developing brain, where they are tonically activated to modulate synaptic transmission, network excitability and synaptogenesis4.

Supplier :

Alomone Labs

Target :

Kainate receptors, AMPA receptors

Long Description :

Kainic acid monohydrate (#K-200) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Selective Agonist of Kainate Receptors and a Partial Agonist of AMPA Receptors

MW :

231.25

Synonyms :

Kainate

Source :

Synthetic

Molecular formula :

C10H15NO4 · H2O

Effective Concentration :

0.1-10 µM.

Activity :

Kainic acid, a cyclic analogue of glutamic acid, is a selective agonist of the kainate receptors (EC50 = 0.6 µM - 7.4 µM, depending on subtype) 1,2, and a partial agonist at AMPA receptors (EC50 = 31 µM - 170 µM, depending on subtype) 1,3. Kainic acid has neuro-excitotoxic and epileptogenic activity in vivo4,5.

Reconstitution and Solubility :

Soluble up to 25 mM in water. Gentle warming may be required. Spin down all products before handling.

Solubility :

Soluble up to 25 mM in water. Gentle warming may be required. Spin down all products before handling.

Storage of solutions :

Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

58002-62-3

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid;hydrate.

more info or order :

Alomone Labs product webpage