chemical

Kynurenic acid

K-110

K-110_1 g

Kynurenic acid

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Kynurenic acid (KYNA) is a neuroactive metabolite of the kynurenine pathway of tryptophan degradation. It is a competitive and broad spectrum antagonist of glutamate receptors. Additionally, KYNA antagonizes α7 nicotinic acetylcholine receptor and G-protein coupled GPR35 receptor. KYNA is widely used as a pharmacological tool to experimentally eliminate activation of all these receptors in vivo or in vitro1-3.Kynurenine can influence brain function and its levels in the human brain are significantly higher compared to those in other species. Its levels in the brain are normally determined by local neosynthesis from its bioprecursor kynurenine pathway metabolite, since KYNA is not actively transported through the blood-brain barrier.KYNA serves as a substrate for the probenecid-sensitive organic anion transporters OAT1 and OAT3. These proteins are present in brain capillary endothelial cells, thus it is likely that these proteins play an important role in the elimination of KYNA from the brain's extracellular compartment2.KYNA has antioxidant properties and has the ability to eliminate hydroxyl, superoxide anion and other free radicals3.It has been documented that in animal models KYNA may have a positive influence on the number of pathologies in the gastrointestinal tract such as ulcers, colon obstruction and colitis1.

Alomone Labs

iGluR, α7 nAChR

Kynurenic acid (#K-110) is a highly pure, synthetic, and biologically active compound.

An Antagonist of Ionotropic Glutamate Receptors and α7 nAChR

189.2

Kynurenate, Quinurenic acid, Transtorine

Synthetic

C10H7NO3.

1 µM - 2 mM.

Kynurenic acid antagonizes ionotropic glutamate receptors with IC50 values of 33 µM (GluK2), 130 µM (GluK1). 100 µM - 3mM antagonizes NMDA response in rat spinal cord.

Up to 50mM in DMSO or in equimolar NaOH. Mild warming (37°C-42°C) and agitation may be required.

Up to 50mM in DMSO or in equimolar NaOH. Mild warming (37°C-42°C) and agitation may be required.

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

492-27-3

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

4-oxo-1H-quinoline-2-carboxylic acid.