chemical

KC 12291 hydrochloride

K-105

K-105_10 mg

KC 12291 hydrochloride

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

The pathophysiological importance of Na+ overload is highlighted by the fact that a variety of drugs reducing Na+ influx proved to be cardioprotective, both at the intact organ and cellular level. In addition, a correlation between the degree of Na+ channel blockade and functional recovery from myocardial infarction is established1.KC 12291 is an orally active atypical voltage-gated sodium channel blocker with cardioprotective properties2-4. It effectively blocks cardiac voltage-gated sodium channels, involving inhibition of the peak Na+ current and thus delays Na+ overload during ischemia by enhancing the inexcitability of the heart4-5.KC 12291 abolishes diastolic contracture in isolated myocytes obtained from guinea-pig atria, with IC50 values of 0.55 and 0.79 μM respectively, and the IC50 for KC 12291 inhibition of the sustained component of Na+ current, INaL, is 9.6 μM6.KC 12291 exerts a potent bradycardic effect in the rat7.

Alomone Labs

NaV channels

KC 12291 hydrochloride (#K-105) is a highly pure, synthetic, and biologically active compound.

An Orally Effective Cardioprotective NaV Channel Blocker

449.99

Synthetic

C22H27N3O3S•HCl.

0.5 - 100 μM.

Orally active voltage-gated Na+ (NaV) channel blocker1-2 with cardioprotective properties2-4. Inhibits sustained Na+ currents (INaL) with IC50 of 9.6 μM and prevents diastolic contracture in isolated atrial myocytes (IC50 of about 0.7 μM)5.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>97%

181936-98-1

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride.