chemical

JNJ-47965567

J-115

J-115_10 mg

JNJ-47965567

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

JNJ-47965567 is a synthetic compound that acts as a potent, selective, and high affinity antagonist of P2X7 receptors. It inhibits BzATP-induced Ca2+ responses in human, rat and mouse P2X7 receptors with pIC50 values of 8.3, 7.2 and 7.5, respectively. JNJ-47965567 is centrally permeable and is active in vivo. The compound can be used as a tool to explore the role of P2X7 in models of CNS pathophysiology.Studies show that JNJ-47965567 may attenuate amphetamine induced hyperactivity and exhibits significant efficacy in rat models of neuropathic pain1.P2X receptors are detected in neuronal, muscular, epithelial and immune cells and have been shown to play a pivotal role in models of various pain conditions. P2X7 receptors are responsible for mediating the release of proinflammatory cytokines in inflammatory/immune conditions and pain1,2.

Alomone Labs

P2X7 receptors

JNJ-47965567 (#J-115) is a highly pure, synthetic, and biologically active compound.

A Potent and Selective Antagonist of P2X7 Receptors

488.65

JNJ-479655, 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide

Synthetic

C28H32N4O2S.

20 nM - 1 µM.

JNJ-47965567 is a potent and highly selective antagonist of purinergic P2X7 receptors, shown to inhibit BzATP-induced Ca2+ responses at human, rat and mouse P2X7 receptors with pIC50 values of 8.3, 7.2 and 7.5, respectively. JNJ-47965567 is centrally permeable and active in vivo1.

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

-20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99% (HPLC)

1428327-31-4

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

N-[[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl]-2-phenylsulfanylpyridine-3-carboxamide.