6'-Iodoresiniferatoxin | Alomone Labs I-805 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

6'-Iodoresiniferatoxin

catalog :

I-805

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs 6'-Iodoresiniferatoxin induces Ca2+influx via activation of TRPV1 expressed in HEK293 cells. - Cells were loaded with 2 mM fluo-3 AM and then stimulated with6?-Iodoresiniferatoxin(#I-805). The left panel shows the intracellular Ca2+levels 10 sec post stimulation with different concentrations of 6?-Iodoresiniferatoxin (ED50= 0.8 ?M) and plotted against drug concentration. The right panel shows intracellular Ca2+levels before and after stimulation of cells with 2.5 ?M 6?- Iodoresiniferatoxin.

product information

CAT :

I-805

SKU :

I-805_0.5 mg

Product Name :

6'-Iodoresiniferatoxin

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

6'-Iodoresiniferatoxin is an agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel.1 It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). It displayed high affinity binding (Ki=0.71 nM) for the human TRPV1 receptor and functioned as a partial agonist.1

Supplier :

Alomone Labs

Target :

TRPV1 channels

Long Description :

6’-Iodoresiniferatoxin (#I-805) is a highly pure, semi-synthetic, and biologically active compound.

Short Description :

An Activator of TRPV1 Channel

MW :

754.6

Synonyms :

6'-IRTX

Source :

Semi-synthetic

Molecular formula :

C37H39IO9.

Effective Concentration :

50 nM - 1 μM.

Activity :

6'-Iodoresiniferatoxin is a partial activator of TRPV1 (Vanilloid/Capsaicin receptor 1) channel1.

Reconstitution and Solubility :

DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to two weeks at 4°C or six months at -20°C.Protect from light.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

335151-55-8

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

Resiniferonyl 20-(4-hydroxy-2-iodo-5-methoxyphenylacetate 9,13,14-ortho(phenylacetate).

more info or order :

Alomone Labs product webpage