5'-Iodoresiniferatoxin | Alomone Labs I-800 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

5'-Iodoresiniferatoxin

catalog :

I-800

more info or order :

Alomone Labs product webpage

citations: 3

Reference
Kitamura N, Nagami E, Matsushita Y, Kayano T, Shibuya I. Constitutive activity of transient receptor potential vanilloid type 1 triggers spontaneous firing in nerve growth factor-treated dorsal root ganglion neurons of rats. IBRO Rep. 2018;5:33-42 pubmed publisher
Fazzari J, Balenko M, Zacal N, Singh G. Identification of capsazepine as a novel inhibitor of system xc- and cancer-induced bone pain. J Pain Res. 2017;10:915-925 pubmed publisher
Spencer N, Schilling T, Miralles F, Eder C. Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production. PLoS ONE. 2016;11:e0162497 pubmed publisher

image

image 1 :

Alomone Labs 5'-Iodoresiniferatoxin inhibits Capsaicin induced Ca2+influx via the activation of TRPV1 expressed in HEK-293 cells. - Cells were loaded with 1 mM fluo-3 AM and then stimulated with 10 M capsaicin in the absence (blue) or presence (purple) of 100 nM and 200 nM (green)5'-Iodoresiniferatoxin(#I-800). The figure shows intracellular Ca2+levels before and after stimulation of cells with 10 M capsaicin.

product information

CAT :

I-800

SKU :

I-800_0.1 mg

Product Name :

5'-Iodoresiniferatoxin

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

5'-Iodoresiniferatoxin (5'-IRTX) is a potent and partial antagonist of the TRPV1 (Vanilloid/capsaicin receptor) channel.1 It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). 5'-Iodoresiniferatoxin partially blocked capsaicin-induced currents in Xenopus oocytes expressing TRPV1 channels (IC50 = 3.9 nM).1 5'-Iodoresiniferatoxin abolished an inhibitory effect of capsaicin on CaV currents (probably mediated by TRPV1) in DRG neurons.

Supplier :

Alomone Labs

Target :

TRPV1 channels

Long Description :

5’-Iodoresiniferatoxin (#I-800) is a highly pure, semi-synthetic, and biologically active compound.

Short Description :

A Potent and Partial Blocker of TRPV1 Channel

MW :

754.6

Synonyms :

5'-IRTX

Source :

Semi-synthetic

Molecular formula :

C37H39IO9.

Effective Concentration :

100 nM - 10 µM.

Activity :

5'-Iodoresiniferatoxin is a potent and partial blocker of TRPV1 (Vanilloid/Capsaicin receptor 1) channel1. It also abolishes the inhibitory effect of capsaicin on CaV currents in DRG neurons2.

Reconstitution and Solubility :

DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to two weeks at 4°C or six months at -20°C.Protect from light.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

535974-91-5

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(pheny lmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzene acetate).

more info or order :

Alomone Labs product webpage