chemical

ICA-110381

I-160

I-160_10 mg

ICA-110381

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

KV7 or KCNQs are voltage-gated K+ channels. These channels are mainly responsible for the cardiac and auditory IK currents and the neuronal M-current but can be found in other tissues as well. Voltage-gated K+ channels are tetramers of α-subunits, which surround a K+-selective pore1. The different five KCNQ subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain tail. This domain is a self-assembling, parallel, four-stranded coiled coil2.ICA-110381 is a synthetic opener of KCNQ channels with an effective concentration of 0.1μM-10μM. In hippocampal CA1 cells, ICA-110381 reduces cell membrane excitability caused by hyperpolarization and decreases membrane resistance. It exhibits strong anticonvulsant properties by acting mainly on the KCNQ2 subunit of the KV7 channel and reduces seizure severity and frequency3.

Alomone Labs

KCNQ channels

ICA-110381 (#I-160) is a highly pure, synthetic, and biologically active compound.

An Opener of KCNQ Channels

267.1

Synthetic

C12H8Cl2N2O.

0.1-10 µM.

ICA-110381 is a KCNQ channel opener with anti-convulsive properties1.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.

200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

325457-99-6

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

4-chloro-N-(6-chloropyridin-3-yl)benzamide.