Isradipine | Alomone Labs I-100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Isradipine

catalog :

I-100

quantity :

5 mg, 10 mg, 25 mg, 50 mg

citations: 1

Reference
Dickerson M, Dadi P, Altman M, Verlage K, Thorson A, Jordan K, et al. Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion. Am J Physiol Endocrinol Metab. 2019;316:E646-E659 pubmed publisher

product information

Vendor :

Alomone Labs Ltd.

Item Name :

Isradipine

Catalog Number :

I-100

Size :

5 mg, 10 mg, 25 mg, 50 mg

Type :

Antagonists Inhibitors

Molecule Name :

4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester.

CAS Number :

75695-93-1

Source/Expression System :

Synthetic

Activity :

Isradipine is a dihydropyridine that acts as a L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat hypertension. Isradipine inhibits L-type channels expressed in xenopus /em oocytes with IC50 = 0.2 muM at a holding potential of -80 mV and the inhibition is state dependent and increases with reduced membrane hyperpolarization. Isradipine, was also shown recently to putatively be an effective treatment for Parkinson’s disease, by affecting particularly the excitability of certain Cav1.3 expressing dopaminergic neurons.

Molecular Weight :

371.4

Gene symbol :

CACNA1C, CACNA1D

Target :

Cav1.2, Cav1.3 Ca2+ channels

Formula :

C19H21N3O5

Format :

Lyophilized/solid.

Purity :

99%

Product Description :

A Potent Blocker of L-Type (both Cav1.2 and Cav1.3) Ca+ Channels

Category :

Ca2+ signaling, Ca2+ signalling, Ion Channels, Chemicals and Reagents, Inhibitors, Biomolecules, Blockers, Antagonists

Research Area :

Cardiovascular, Cardiac, Heart, Alzheimer's Disease, Neurodegenerative Disorders, Neuroscience