chemical

α-MSH

GPM-100

GPM-100_1 mg

α-MSH

Non Antibodies

Proteins

Melanin production assay

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Synthetic peptide

MC1R, MC2R, MC3R, MC4R, MC5R

α-MSH is a neuropeptide originally isolated from the pituitary gland1. α-MSH is produced by post-translational processing of a precursor protein, proopiomelanocortin (POMC)2. In most vertebrates but not in mammals, α-MSH is produced in the intermediate lobe of the pituitary gland. The biological activities of α-MSH are mediated through a family of five specific G-protein coupled receptors: MCR1, MCR2, MCR3, MCR4, and MCR5. α-MSH is an evolutionarily highly conserved peptide action that induces pigment dispersion in skin melanocytes of amphibians, reptiles and mammals by stimulating melanin production3,4.However, in human and other mammals, α-MSH acts in the brain in appetite suppression and sexual arousal. Some cases of extreme obesity have been traced to mutated α-MSH receptor in the brain. Presumably, these people are unable to respond to the appetite-suppressing effect of α-MSH5. α-MSH has significant anti-inflammatory properties, mediated through its binding to MCR16 and includes regulation of expression and secretion of chemokines, downregulation of proinflammatory signal-induced NF-kB activation and adhesion molecule expression, prostaglandin E2 synthesis, as well as induction of interleukin-107.

Alomone Labs

Melanocortin receptor

A Ligand of Melanocortin G-Protein Coupled Receptor

A Ligand of Melanocortin G-Protein Coupled Receptor

1665 Da

α-Melanotropin, alpha-MSH

Ser1- Acetylation Val13- C-terminal amidation

C77H109N21O19S

30 - 300 pM

α-MSH is involved in food intake regulation, energy homeostasis, immune responses modulation and photoprotection1-3.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

0581-05-05

Lyophilized

Contact Alomone Labs for technical support and product customization

SYSMEHFRWGKPV-NH2

No

12352202

yes

no