chemical

Geldanamycin

G-500

G-500_0.1 mg

Geldanamycin

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Geldanamycin is a potent antitumor antibiotic1 active against more than 50 tumor cell lines.2 Hsp90 is a molecular chaperone that regulates the folding, assembly and conformational maturation of proteins. It has a key role in cell response to environmental stress and in maintaining the malignant phenotype of tumor cells.3Geldanamycin binds into the ATPase binding pocket in Hsp90,4,5 and induces the degradation of proteins required by this chaparone to induce conformational maturation. Hsp90 client proteins include transcription factors (mutated p53, HIF-1a, EF-2),6,7 tyrosine kinases (v-Src, Bcr-Abl, erbB2),8,9 serine-threonine kinases (Raf-1),10,11 and the nuclear receptor family (androgen, estrogen).12 Hsp90 client proteins play important roles in the regulation of the cell cycle, cell growth, apoptosis, and oncogenesis, geldanamycin inhibits the proliferation of cultured cancer cells and shows anticancer activity in experimental animals.The antitumor effects involve different mechanisms such as destabilization of mutant p53 protein (breast and prostate cell lines)13 cell cycle arrest,13 inhibition of c-Jun expression,14 destabilization of Raf-1, destruction of EF-2 kinase, and inhibition of telomerase activity.15 Recently, synergistic effects of Geldanamycin with cytotoxic drugs16,17 increased tumor cell sensitivity to radiation.18,19

Alomone Labs

Geldanamycin (#G-500) is a highly pure, natural, and biologically active compound.

A Powerful Anticancer Antibiotic

560.6

Geldanomycin, U-29135

Natural

C29H40N2O9.

100 nM - 1 µM.

Geldanamycin is a potent antitumor antibiotic1 active against more than 50 tumor cell lines2. It binds to the ATPase binding pocket in Hsp903,4 and induces the degradation of proteins required by this chaperone.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

30562-34-6

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

17-Demethoxy-17-(2-propenylamino) geldanamycin.