chemical

GW-2580

G-255

G-255_10 mg

GW-2580

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

GW-2580 is a small-molecule pyrimidine derivative, that acts as a potent and selective inhibitor of Colony-stimulating factor 1 (CSF-1) signaling through cFMS kinase receptor. GW-2580 completely inhibits human cFMS kinase in vitro at 0.06 μM1. The compound also acts as an inhibitor of Trk Receptors and shows binding towards TrkB, TrkC, and TrkA with Kd values of 36 nM, 120 nM and 630 nM, respectively2 and fully inhibits BDNF-induced TrkB phosphorylation in cells at 3 µM3.

Alomone Labs

CSF-1R receptor, Trk receptor

GW-2580 (#G-255) is a highly pure, synthetic, and biologically active compound.

An Inhibitor of Trk Receptors and cFMS/CSF-1 Receptor Kinases

366.41

cFMS Receptor Tyrosine Kinase Inhibitor

Synthetic

C20H22N4O3.

1-100 µM.

GW-2580 is a potent and selective inhibitor of cFMS/CSF-1 receptor kinase, shown to completely and selectively inhibit human cFMS kinase activity at 60 nM, and fully suppress CSF-1 induced cell growth at 1 μM, in vitro. Orally bioavailable and active in vivo1. GW 2580 also binds to TrkB, TrkC and TrkA with Kd values of 36 nM, 120 nM and 630 nM, respectively,2 and fully inhibits BDNF-induced TrkB phosphorylation in cells at 3 µM3.

Soluble up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Soluble up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Store at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

870483-87-7

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine.