chemical

Gambogic acid

G-250

G-250_10 mg

Gambogic acid

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Gambogic acid is a compound originally derived from the gamboges resin of the tree, Garcinia hanburyi. Gambogic acid has been shown to pose cytotoxic activity against tumor cells in culture through a mechanism involving apoptosis1.Gambogic acid was found to act as a slow blocker of Kir2.1 with relatively potent IC50 values of 100 nM and lower2.Gambogic acid is better known for its agonistic action on caspases, proteases involved in apoptosis and as a Bcl-2 inhibitor. Bcl-2-family proteins are regulators of apoptosis1.

Alomone Labs

Caspases, Bcl-2, Bax, CD71, Kir2.1

Gambogic acid (#G-250) is a highly pure, synthetic, and biologically active compound.

Kir2.1 Channel Blocker, Apoptosis Inducer, Caspase Activator and Bcl-2 Inhibitor

628.75

1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid, B"-Guttiferrin, Beta-Guttiferrin, Beta-Guttilactone, Cambogic acid, Guttatic acid, Guttic acid

Synthetic

C38H44O8.

0.1-1 µM.

Gambogic acid is a cell-permeable apoptosis inducer in multiple cancer cell lines, acting via activation of caspases (EC50 of 0.78-1.64 µM), competitive inhibition of Bcl-2 family proteins (IC50 of 0.66-2.02), altering the expression of Bcl-2 and Bax genes, and binding CD71 transferrin receptors to prevent their internalization (IC50 = 4.1 µM). Gambogic acid is also a slow blocker of Kir2.1 channels (IC50 ≤ 100 nM)1-3.

Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).

-20°C up to four months. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

2752-65-0

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

(2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid.