GYKI 47409 (BDZ-g) | Alomone Labs G-245 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

GYKI 47409 (BDZ-g)

catalog :

G-245

more info or order :

Alomone Labs product webpage

image

image 1 :

Peptide (C)RGAKRSRPSKLTED corresponding to amino acid residues 128-141 of rat AKAP5 (AccessionP24587). Intracellular.

image 2 :

product information

CAT :

G-245

SKU :

G-245_10 mg

Product Name :

GYKI 47409 (BDZ-g)

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

GYKI 47409 (BDZ-g) is a potent and selective AMPA receptor antagonist and binds to a noncompetitive site of the receptor. GYKI 47409 inhibits the open channel and the closed-channel conformations of AMPA receptors1.AMPA receptors are the primary receptors mediating fast excitatory neurotransmission in the mammalian central nervous system. This function is essential for synaptic plasticity, learning and memory1,2.

Supplier :

Alomone Labs

Target :

AMPA receptors

Long Description :

GYKI 47409 (BDZ-g) (#G-245) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of AMPA Receptors

MW :

407.49

Synonyms :

GYKI47409, (R)-5-(4-amino-3-methyl-phenyl)-8-methyl-7-(5-methyl-1,3,4-thiadiazol-2-yl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

Source :

Synthetic

Molecular formula :

C21H21N5O2S.

Effective Concentration :

1-50 µM.

Activity :

GYKI 47409 (BDZ-g) is a potent and selective noncompetitive antagonist of AMPA glutamate receptors. GYKI 47409 (BDZ-g) was shown to act on both open-channel and closed-channel conformation, and to inhibit the homomeric channels, as well as the GluA2-containing AMPA receptor channels, with no significant activity on kainate and NMDA type glutamate receptors1.

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

Store at -20°C for several months. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

732278-52-3

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-methyl-4-[(8~{R})-8-methyl-7-(5-methyl-1,3,4-thiadiazol-2-yl)-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline.

more info or order :

Alomone Labs product webpage