chemical

Gambogic amide

G-235

G-235_1 mg

Gambogic amide

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Gambogic amide, is a small molecule that mimics nerve growth factor (NGF) and is a selective agonist of TrkA receptor that strongly induces its tyrosine phosphorylation and downstream signaling activation.Gambogic amide interacts with the cytoplasmic juxtamembrane domain of TrkA receptor and triggers its dimerization. It selectively binds, activates and upregulates the expression of TrkA receptors at nanomolar concentrations but not TrkB or TrkC.Gambogic acid is a major active ingredient of gamboge, a resin exuded from the Garcinia hanburyi tree in southeast Asia. Gambogic amide also possesses neurotrophic activity in various neural injury animal models and prevents glutamate-induced neuronal cell death1,2.Gambogic amide shows antiapoptotic activity and demonstrates EC50 value of 5 nM3.

Alomone Labs

TrkA receptors

Gambogic amide (#G-235) is a highly pure, synthetic, and biologically active compound.

A Selective Agonist of TrkA Receptors

627.78

Gambogic acid amide

Synthetic

C38H45NO7.

0.1-1 µM.

Gambogic amide, an NGF-mimetic small molecule, is a TrkA receptor agonist, shown to selectively bind, activate and upregulate the expression of TrkA receptors at nanomolar concentrations (Kd = 75 nM). Gambogic amide shows antiapoptotic activity (EC50 = 5 nM), neuroprotective and anti-cancer effects in vitro and in vivo1-3.

Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).

-20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>95%

286935-60-2

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

(2Z)-4-[(1S,2S,8R,17S,19R)-12-Hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9, 11,15-pentaen-19-yl]-2-methyl-2-butenamide.