GW441756 hydrochloride | Alomone Labs G-191 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

GW441756 hydrochloride

catalog :

G-191

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs Muscimol hydrobromide activates GABA(A) receptors expressed inXenopusoocytes. - Time course of GABA(A) ?1/?2 currents reversibly activated in a concentration dependent manner by 0.01 M 0.1 M and 1 M Muscimol hydrobromide (#M-240) while membrane potential was held at -60 mV.

product information

CAT :

G-191

SKU :

G-191_10 mg

Product Name :

GW441756 hydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

GW441756 is a potent and selective inhibitor of the NGF receptor tyrosine kinase A (TrkA). This compound also inhibits TrkB and TrkC but displays significantly higher selectivity for TrkA receptor than other TrkA inhibitors and a 100-fold selectivity over a range of other kinases. The IC50 value of GW441756 is 2 nM1,3.The compound induces a dose-dependent decrease in neoplastic proliferation and has the ability to increase levels of caspase-3 that can lead to apoptosis.Previous studies have shown that TrKA inhibitors have a relevant anti-proliferative effects in neoplasia compare to other TrkA inhibitors with a lower effective dosage1,3.Signaling through protein tyrosine kinase receptors is important for neuronal metabolism, promotion of neuronal survival, stimulating neurite growth, synaptogenesis and potentiating synaptic strength2.

Supplier :

Alomone Labs

Target :

TrkA receptors

Long Description :

GW441756 hydrochloride (#G-191) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent Inhibitor of TrkA

MW :

311.8

Source :

Synthetic

Molecular formula :

C17H14ClN3O.

Effective Concentration :

2 nM - 2 µM.

Activity :

GW441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA)1.

Reconstitution and Solubility :

4-10 mM in H2O. Centrifuge all product preparations before use (5,000 x g for 1 min).

Solubility :

4-10 mM in H2O. Centrifuge all product preparations before use (5,000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

≥97%

CAS No :

504433-24-3

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one; hydrochloride.

more info or order :

Alomone Labs product webpage