chemical

GW441756

G-190

G-190_1 mg

GW441756

Non Antibodies

S. Molecules

Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

GW441756 is a potent and selective inhibitor of the NGF receptor tyrosine kinase A (TrkA). This compound also inhibits TrkB and TrkC but displays significantly higher selectivity for TrkA receptor than other TrkA inhibitors and a 100-fold selectivity over a range of other kinases. The IC50 value of GW441756 is 2 nM1,3.The compound induces a dose-dependent decrease in neoplastic proliferation and has the ability to increase levels of caspase-3 that can lead to apoptosis.Previous studies have shown that TrKA inhibitors have a relevant anti-proliferative effects in neoplasia compare to other TrkA inhibitors with a lower effective dosage1,3.Signaling through protein tyrosine kinase receptors is important for neuronal metabolism, promotion of neuronal survival, stimulating neurite growth, synaptogenesis and potentiating synaptic strength2.

Alomone Labs

TrkA receptors

GW441756 (#G-190) is a highly pure, synthetic, and biologically active compound.

A Potent Inhibitor of TrkA

275.3

Synthetic

C17H13N3O.

2nM - 2 µM.

GW441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA)1.

4-10 mM in DMSO. Centrifuge all product preparations before use.

4-10 mM in DMSO. Centrifuge all product preparations before use.

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

≥97% (HPLC)

504433-23-2

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

(3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one.