chemical

Ginkgolide B

G-170

G-170_10 mg

Ginkgolide B

Non Antibodies

S. Molecules

Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Ginkgolide B is a natural non-selective blocker of 5-HT3A channel. Ginkgolide is extracted from the leaves, roots and bark of the tree Ginkgo biloba. Ginkgolide B has an effective concentration of 500-1000 μM and an IC50 of 730 μM for the 5-HT3A receptor and an IC50 of 3.9 mM for the 5-HT3B receptor thus enabling discrimination between the two. Ginkgolide also binds to anion Cys-loop receptors such as GABA and glycine receptors. Ginkgolide does not displace the specific 5-HT3 receptor antagonist granisetron, thus confirming that it does not act at the agonist binding site. In addition, inhibition by Ginkgolide at 5-HT3A receptors is weakly use-dependent, and recovery of the receptor is also activity dependent, indicating channel block as the mechanism of inhibition. Ginkgolide is widely used in traditional medicine and has a wide spectrum of beneficial properties such as anti-convulsion, neuro-protection and reducing anxiety2.

Alomone Labs

5-HT3A receptors

Ginkgolide B (#G-170) is a highly pure, natural, and biologically active compound.

An Antagonist of 5-HT3A Channels

424.4

Natural

C20H24O10.

500-1000 µM.

Ginkgolide B is a 5-HT3A channel blocker1.

200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

15291-77-7

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

((1R,3R,6R,7S,8S,10R,11R,12R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione.